TBX5 and congenital heart disease: Previous characterization of a Dutch family with the pathogenic TBX5-p.G125R missense variant revealed atypical HOS, with mild skeletal abnormalities and lower penetrance of congenital heart defects but a high prevalence of AF.15 Here, we show that these patients suffer from other types of supraventricular arrhythmias that indicate dysfunctionality of the atrial muscle, including the sinoatrial node and AV node, that were not identified previously (Table S1).