Although reduced glucotoxicity associated with sustained improvements in glucose homeostasis lessens the risks and severity of renal complications in type 2 diabetes irrespective of the glucose-lowering medication [33•], the renal benefits offered by SGLT2 inhibitors appear to be somewhat greater and faster in onset than with intensified glucose lowering and show little association with their glycaemic effect. Here, SLC5A2 is linked to type 2 diabetes mellitus.