MEDLINE, PubMed, and Google Scholar were searched for articles published between January 2010 and March 2021 using the terms ‘sodium glucose transporter inhibitor’, ‘SGLT2 inhibitor’ and the generic names of individual SGLT2 inhibitors in combination with the term ‘kidney disease’, ‘acute kidney injury’, ‘chronic kidney disease’, ’renal function’, ‘diabetes’ and ‘type 2 diabetes’. This evidence concerns the gene SLC5A2 and acute kidney injury.