IGKV1D-22 and renal fibrosis: Pharmacological targeting on this pivotal proinflammatory macrophage subset by two small‐molecule inhibitors of S100a8/a9 signaling, significantly improved renal function and reduced mortality in bilateral IRI (bIRI) murine model, and ameliorated kidney injury and long‐term renal fibrosis in the unilateral IRI (uIRI) murine model.