Although we have not implemented an exhaustive panel of different timings of S100a8/a9 intervention, we did find that the blockade of S100a8/a9 by single doses of the two small‐molecule inhibitors, tasquinimod or paquinimod, successfully decreased the infiltration of proinflammatory Ly6chi macrophages and neutrophils, decreased the production of inflammatory cytokines, and ameliorated the degree of kidney tissue injury in the uIRI‐AKI mouse model. This evidence concerns the gene S100A8 and acute kidney injury.