Against previous expectations, we now show that TDP‐43 phosphorylation, and in particular phosphomimetic mutations mimicking the phosphorylation pattern in ALS/FTD (Hasegawa et al, 2008; Kametani et al, 2016), strongly suppress TDP‐43 phase separation and aggregation both in vitro and in cells. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.