CXCR2 and infection: Of note, surface expression of auxiliary receptor CXCR2, (another important auxiliary receptor involved in the amplification of neutrophil response in wound and toward infection [de Oliveira et al., 2016; Brubaker et al., 2013]), on neutrophils and chemotaxis through the CXCR2 in response to CXCL1 (a.k.a. KC) – a known ligand for CXCR2 (Chintakuntlawar and Chodosh, 2009) – were also unaffected by high glucose exposure in neutrophils (Figure 3—figure supplement 1a-c).