CTSZ and tuberculosis: For example, a single interval on chromosome two controls CFU levels and IL-10, and contains a variant in the Ctsz gene encoding Cathepsin Z. Ctsz is a strong candidate considering its known roles in autophagy (Amaral et al., 2018), dendritic cell differentiation and function (Obermajer et al., 2008), its upregulation in non-human primates (Ahmed et al., 2020) and human patients with Mtb (Zak et al., 2016), and the association of CTSZ variants with disease risk in human TB studies (Adams et al., 2011; Cooke et al., 2008).