Biological mechanisms such as androgen receptors in amygdala, hippocampus, and neocortex, androgens modulation activity and interconnectivity of prefrontal cortex and amygdala in depressive disorders [99], and the influence of pathological imbalance of androgens and cortisol on HPA-axis may in part explain the role of androgens in development and course of depression. Here, AR is linked to depressive symptom measurement.