Biological mechanisms such as androgen receptors in amygdala, hippocampus, and neocortex, androgens modulation activity and interconnectivity of prefrontal cortex and amygdala in depressive disorders [99], and the influence of pathological imbalance of androgens and cortisol on HPA-axis may in part explain the role of androgens in development and course of depression. This evidence concerns the gene AR and major depressive disorder.