Relevant studies suggested that PI3K/AKT/FOXO1 signaling pathway is widely present in various tumor cells, and activation of this pathway can inhibit apoptosis and promote cell cycle progression, thereby promoting cell growth and proliferation, while participating in tumor angiogenesis, playing an important role in tumor formation, and participating in tumor invasion and metastasis [21, 22]. This evidence concerns the gene FOXO1 and neoplasm.