This can occur in response to extracellular stimulation by stress, viral infection, excessive immune cytokines secretions, etc. Bax exist in a relatively stable molecular form, but with viral infection it changes form and moves to the outer membrane of the mitochondria where it inserts itself, causing the release of the cytochrome c, initiating apoptosis (10) with the release of its DNA. The gene discussed is BAX; the disease is viral infectious disease.