Martinez et al. revealed that the time-dependent upregulation of miR-31 plays a significant role in adverse remodeling following rat MI, inhibition of miR-31 modulates several genes, such as Tnnt2, Timp4, and E2f6, which is vital to the recovery of cardiac function and structure after MI (82). The gene discussed is TNNT2; the disease is myocardial infarction.