The results showed that the changed metabolites were involved in sphingolipid metabolism, Fc gamma R-mediated phagocytosis, apelin signaling pathway, choline metabolism in cancer, calcium signaling pathway, phospholipase D signaling pathway, tuberculosis, sphingolipid signaling pathway, and insulin resistance signaling pathways (Supplementary Figure 2C). The gene discussed is APLN; the disease is tuberculosis.