1. l-phenylalanine andp-hydroxyphenylacetic acid levels are positively correlated with CRP levels in ESRD and healthy controls groups 2. In ESRD patients, pseudouridine, l-phenylalanine, and p-hydroxyphenyl acetic acid metabolites positively correlated with IL-6 levels. 3. Inflammatory markers and metabolites can be used a diagnostic and predictive marker for CKD. Here, IL6 is linked to chronic kidney disease.