REN and Hypertension: 1. CKD Rats showed a high accumulation of TAMO, reduction in SCFAs (acetate, butyrate), and dysregulation of the renin-angiotensin system. 2. CKD group expressed a higher Firmicutes to Bacteroidetes ratio compared to the controls group. 3. Phylum Bacteroidetes was low abundance in the CKD group. Maternal CKD is associated with hypertension and renal damage in the adult male offspring.