1. TMAO and choline diets were associated with renal functions impairment and renal fibrosis, while IMC supplementation showed significant improvement in renal functional metrics. 2. The relative abundance of Bacteroides was lower in the TAMO and choline  Groups than in the control  Group, and the addition of IMC reversed this effect. 3.  Group 2 and  Group 3 diets had a marked enrichment of Lachnospiraceae_UCG-002 with a positive correlation of Cystatin C and ACR and a negative correlation with GFR. Here, CST3 is linked to renal fibrosis.