1. Resveratrol treatment showed a protective effect against hypertension in the adult male offspring of maternal CKD. 2. Resveratrol beneficially modifies the gut microbiota by increasing the abundance of the generaLactobacillus and Bifidobacteriumand decreasing theFirmicutes toBacteroidetes ratio. 3. The plasma TMA significantly increased in the resveratrol treated group than the CKD group with decreasing TMAO-to-TMA ratio. 4. The male offspring's kidneys expressed increasing G-protein coupled receptor-41 (GPR41) protein levels in the resveratrol treated group. Here, FFAR3 is linked to chronic kidney disease.