NFKB1 and intervertebral disk degenerative disorder: In our study, to further elucidate the molecular mechanism underlying the effects of LINC02569 on IDD, we performed the RNA sequence analysis for the NPCs with and without LINC02569 knockdown, and found that the key genes and target genes of NF-κB pathway were downregulated, which suggested the potential association between LINC02569 and NF-κB signaling pathway.