P-Selectin + EVs >1,054/μL were associated with thrombosis (p = 0.024), E-Selectin + EVs ≤531/μL with worsening/death (p 0.026) and 30-days P-Selectin+ and CD45 + EVs with persistent symptoms (p < 0.0001). The gene discussed is SELP; the disease is deep vein thrombosis.