Plasma concentrations of PS + EVs (identified by Annexin v+), endothelium-derived (identified by E-Selectin+ and ACE2+), platelet-derived (identified by P-Selectin+), leukocyte-derived (identified by CD45+) EVs, TF+, leukocyte-derived expressing TF (CD45+TF+), PDGF-β+ as well as SARS-CoV-2-NP+ were significantly increased in COVID-19 patients at baseline vs. healthy controls. Here, ANXA5 is linked to COVID-19.