TF and blood coagulation disease: One additional mechanism of COVID-19 coagulopathy is the continuous release of TF in the pulmonary circulation, and in the blood vessels of other organs and tissues, thus contributing to the activation of secondary hemostasis (Grover and Mackman, 2018; Iba et al., 2020a; Lippi et al., 2021; Iba et al., 2020b; Connors and Levy, 2020).