CCL2 and neoplasm: Molecules such as integrins VLA-4, CD106, the cytokine receptor CCL2 and galactin-1, engaged in the process of MSCs extravasation, could take part in the interplay between MSCs and tumor cells in VITVO50 (Belema-Bedada et al., 2008; Melzer et al., 2016; Nitzsche et al., 2017).