In addition, tumors have been found to induce production of type II NKT cells, which in turn secrets IL-13, thereby not only causing aggregation of MDSC in the tumor microenvironment but also activating the STAT6 signaling pathway and suppressing CD8+ T cell function (Terabe et al., 2000; Terabe et al., 2005). The gene discussed is STAT6; the disease is neoplasm.