PPARD and infection: Apparently, Nuc1 is important for S. aureus biomaterial-associated infection to persist in the acute phase of the foreign body reaction and even extends it, which was also indicated by the lack of foreign body giant cells in mice with the inoculated wildtype strain (Table 1) corroborating earlier observations in biomaterial-associated infection studies (van Putten et al., 2011; Sheikh et al., 2015).