CRP and Hypoalbuminemia: Studies have demonstrated SIR, which is indicated by a high neutrophil-lymphocyte ratio (NLR) (22–26), an elevated C-reactive protein (CRP) (22, 23, 27–33) and Glasgow Prognostic Score (GPS) (i.e. the combination of elevated CRP and hypoalbuminemia) (34–40), is associated with a poor prognosis in cancer patients.