In addition to KRAS, miR-193a-3p acts on multiple signaling pathways and plays a tumor-suppressive role by regulating the expression of interleukin 17 receptor D (IL17RD) and erb-b2 receptor tyrosine kinase 4 (ERBB4) in CRC (54, 55). This evidence concerns the gene ERBB4 and colorectal carcinoma.