CircRNAs of circ_0007031, circ_0007006, and circ_0000504 have been found to modulate 5-FU resistance of CRC cells by regulating AKT3 via the AKT signaling pathway, while circ_0048234 can sponge miR-671-5p in 5-FU-resistant CRC cells via the EGFR signaling pathway (103) (Table 3, Figure 4). The gene discussed is EGFR; the disease is colorectal carcinoma.