Because the conceptof DIC is not widely known abroad, their effectiveness has not been proven.19 But in Japan, in a clinical study on DIC cases fromaround 2009, it was reported that the recovery rate from DIC was significantly high.20 Also in Japan, although thrombomodulin preparationscan be used for the treatment of DIC, they were not adopted in the Japanese Clinical PracticeGuidelines for Management of Sepsis and Septic Shock 2016. This evidence concerns the gene THBD and Sepsis.