Multivariate analysis revealed the following independent prognostic factors:interleukin (IL)-8 (odds ratio [OR]=4.17, 95% confidence interval [CI]=1.52–11.41,p=0.002), general fatigue (OR=1.22, 95%CI=1.03–1.45,p=0.019), anorexia (OR=1.19, 95%CI=1.04–1.37, p=0.008),dyspnea (OR=1.19, 95%CI=1.02–1.38, p=0.024), depression (OR=1.28,95%CI=1.11–1.47, p<0.001), nausea (OR=1.25, 95%CI=1.05–1.48,p=0.007), dry mouth (OR=1.19, 95%CI=1.01–1.40, p=0.032),and overall assessment score (OR=1.05, 95%CI=1.02–1.09, p<0.001). The gene discussed is CXCL8; the disease is depressive disorder.