The following were independent prognostic factors: serum level of IL-8(OR=4.17, 95% CI=1.52–11.41, p=0.002), general fatigue (OR=1.22, 95%CI=1.03–1.45, p=0.019), anorexia (OR=1.19, 95% CI=1.04–1.37,p=0.008), dyspnea (OR=1.19, 95% CI=1.02–1.38, p=0.024),depression (OR=1.28, 95% CI=1.11–1.47, p<0.001), nausea (OR=1.25, 95%CI=1.05–1.48, p=0.007), dry mouth (OR=1.19, 95% CI=1.01–1.40,p=0.032), and overall assessment score (OR=1.05, 95% CI=1.02–1.09,p<0.001). Here, CXCL8 is linked to depressive symptom measurement.