Prediction of prognosis has historically been guidedby disease extension, as indicated by tumor stage, for example, but it hasbecome clearer that tumor biology is more relevant to prognosis than tumorsize.32Although cancers with high Ki67 expression are typically at a more advancedstage than cancers with low Ki67 expression, multivariate analysis showedthat Ki67 expression as a continuous variable was an independent prognosticfactor for DDFS and OS. Here, MKI67 is linked to neoplasm.