Breast cancer, for example, is characterized by an elevated secretion of proinflammatory cytokines (IL-1, TNF-α, IL-6) or anti-inflammatory cytokines (IL-10), chemokines and chemokine receptors (CXCL8, CXCR4), and angiogenic factors (VEGF) [21]. The gene discussed is TNF; the disease is breast cancer.