Previous studies have shown that αvβ6 has a high affinity for TGF-β1 latency related peptide and is involved in the activation of TGF-β1 latency complex (Annes et al., 2004), soluble LAP protein inhibited the adhesion and migration of oral squamous cell carcinoma mediated by αvβ6 (Thomas et al., 2002). The gene discussed is TGFB1; the disease is oral cavity squamous cell carcinoma.