TGFB3 and oral cavity squamous cell carcinoma: Previous studies have shown that αvβ6 has a high affinity for TGF-β1 latency related peptide and is involved in the activation of TGF-β1 latency complex (Annes et al., 2004), soluble LAP protein inhibited the adhesion and migration of oral squamous cell carcinoma mediated by αvβ6 (Thomas et al., 2002).