To further assess the CTSG, MMP9, PRTN3, RETN, RNASE2, and RNASE3 expression levels in CML, we perform RT-qPCR to search the mRNA expression of the hub genes in PBMCs of the healthy individuals and CML-CP/BP patients (Fig. 13). Here, MMP9 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.