The deficiency of carnitine palmitoyltransferase-1b (CPT1b), a mitochondrial β-oxidation rate-limiting enzyme that controls the uptake of long-chain acyl-CoA in the mitochondria, results in myocardial lipid accumulation, increased ceramide levels, and worsened pathological myocardial hypertrophy in the cardiac pressure overload model [70]. This evidence concerns the gene CPT1B and cardiac hypertrophy.