- promoted AHN by P7C3 and LV-Wnt3- improved pattern separation memory in male of AD mouse model but not in female of AD mouse model by increasing AHN - no change in other forms of cognition by increasing AHN in AD mouse model- improved pattern separation memory in female of AD mouse model by increasing AHN and BDNF. The gene discussed is BDNF; the disease is Alzheimer disease.