In a previous study, the compound, Dl-3-n-butylphthalide, attenuated mouse behavioral deficits via activation of the AKT signaling pathway in the hippocampus of chronic social defeat stress-induced depressive mice [164], and a similar phenomenon was observed in the prefrontal cortex of chronic-restraint stress induced depression-like mice [165]. This evidence concerns the gene AKT1 and depressive disorder.