DPP-4 inhibitors may reduce hospitalizations.38 Pancreatitis was very rare and frequencies were similar in both groups.38,40,44,45 It is unclear whether DPP-4 inhibitors have an impact on falls,38,44 fractures,38,44,45 renal impairment44 and delirium (no RCT) compared with sulfonylureas as add-on treatment to standard care because no study assessed these predefined outcomes or the quality of evidence was very low. This evidence concerns the gene DPP4 and pancreatitis.