DPP4 and type 2 diabetes mellitus: Adding DPP-4 inhibitors to standard care may increase mortality slightly in older type 2 diabetes patients with inadequate glycaemic control.34,39,42,47, –49 DPP-4 inhibitors increase the risk for hypoglycaemia.34,36,37,41,42,47, –49 Differences in overall adverse events 34,36,37,42,47, –49 and discontinuation due to adverse events34,36,37,47, –49 are negligible.