Dimerization as a strategy to increasethe biological activityof natural and synthetic molecules has been largely pursued in thelast several years.12 In this context,the binding of a bifunctional ligand to the catalytic sites of anADAM8 active homodimer on the tumor cell membrane could efficientlyreduce ADAM8-mediated tumor growth and invasion to the surroundingtissues. This evidence concerns the gene ADAM8 and neoplasm.