ADAM17 and cancer: In particular, the dimerization depends on DISdomain interactions.2 Different from otherfamily members, such as ADAM17 and ADAM10,3 ADAM8 is not essential under physiological conditions, but it isupregulated in inflammatory processes and in several cancers.4 Through its proteolytic activity, it is responsiblefor the cleavage of cell surface proteins (ectodomain shedding) andthe degradation of extracellular matrix (ECM) components.