Notably, DHCT treatment of HCC cells resulted in the reduced expression of α7nAChR, JAK2, and cancer stemness markers (CD133, KLF4, and SOX2) as well as decreased ALDH1 activity (Figure 5), thereby suppressing the colony-forming and tumor sphere generation abilities of HCC cells. The gene discussed is KLF4; the disease is hepatocellular carcinoma.