Interestingly, the mRNA expression levels of Ki67, Cyclin D1, JAK2, and α7nAChR significantly inhibited on both the Huh7 and HepG2 HCC-DHCT-treated cells as compared to control-treated (nicotine only) (Figure 3(d); ∗∗p < 0.01). Here, JAK2 is linked to hepatocellular carcinoma.