In addition, the ZNF488 expression was evidently higher in PC cell lines than in normal pancreatic duct epithelial cells (HPME), with the highest expression in PANC-1 cells and the lowest expression in AsPC-1 cells (Figure 1(e)), indicating that ZNF488 is involved in the occurrence and development of PC. The gene discussed is ZNF488; the disease is pachyonychia congenita.