CD4 and cancer: Testosterone also enhances IL-10 synthesis in T cells and Th2 cytokines while inhibiting Th-1 differentiation (Liva and Voskuhl 2001; Kissick et al., 2014) mice treated with testosterone analogs, showed decreased levels of CD4+ CD8 + lymphocytes and increased levels of CD4+ CD8- T cells, promoting the pro-inflammatory response and cancer progression (Aboudkhil et al., 1991).