The release of cytokines, interferon-γ (IFN-γ), tumor necrosis factor (TNF), interleukins (IL-1, IL-6), chemokines, prostaglandins, growth factors, and enzymes such as cyclooxygenase and metalloproteinase, as well as the production of reactive oxygen and nitrogen species in a chronically inflamed tissue causes genetic instability and epigenetic alterations, adding to the favorable conditions for the onset of cancer (Fernandes et al., 2015; K.; Nakamura and Smyth 2017). This evidence concerns the gene TNF and cancer.