In addition, oncogene activation, hypoxia, nutritional deprivation and tumor necrosis already prompted to occur, can lead to the development of an inflammatory environment that collaborates between the autocrine and paracrine glands through cytokines, growth factors, and proteases along with the activation of inflammatory and tumor progression transcription factors such as NF-κB and STAT3 (Pikarsky et al., 2004; Ji et al., 2019). The gene discussed is STAT3; the disease is neoplasm.