Except for the monotherapies and combination therapies mentioned above, the gene editing technology CRISPR-Cas9 points out a new direction to enhance the efficacy of tumor immunotherapy, as knocking out PD-1 and LAG3 of CAR-T cells can significantly enhance the anti-tumor effect and inhibit the immunosuppressive microenvironment (77, 78). The gene discussed is LAG3; the disease is neoplasm.