The co-expression of FGL1 and LAG3 are negatively correlated with PD-L1 expression and CD8+T cell number in HCC (89), the co-expression of LAG3 and TIM3 may serve as a T cell exhaustion marker in PCNSL (90, 91), both of the co-expression predict poor survival. The gene discussed is FGL1; the disease is hepatocellular carcinoma.