The role of FGL1 differs in these tumors can be attributed to the tumor heterogeneity, the results of FGL1 in MC38 colon cancer cells are mor complete and compelling, it is hard to explain the results of the downregulation of FGL1 regulates EMT in SGC-7901 gastric cancer cell and LKB1-overexpressing A549 lung carcinoma cell, which are totally reverse and incredible, it warrants more exploration. The gene discussed is FGL1; the disease is malignant colon neoplasm.