In tumors, such as kidney renal clear cell carcinoma (KIRC), non-small cell lung cancer (NSCLC), colorectal cancer, hepatocellular carcinoma (HCC), primary central nervous system lymphoma (PCNSL), diffuse large B-cell lymphoma (DLBCL), and muscle invasive bladder cancer (MIBC), higher expression of LAG3 indicates a poor prognosis. This evidence concerns the gene LAG3 and diffuse large B-cell lymphoma.