However, the downregulation of FGL1 promote the growth of LKB1 mutant lung cancer cells and HCC cells, in the LKB1-overexpressing A549 lung carcinoma cell line, FGL1 silencing leads to an increased cell growth rate and to increased cell migration and promotes tumor angiogenesis and EMT (57); in FGL1-null mice, the growth rate of HCC is faster compared to that in wild type mice, and that the expression of FGL1 is inhibited during HCC development, which may be attributed to the activation of Akt and mTOR (21). This evidence concerns the gene AKT1 and hepatocellular carcinoma.