PRF1 and gastric cancer: More LAG3+ cells induce the immunosuppressive microenvironment and predict the poor prognosis, in EBV-positive and MLH1-defective gastric cancer, high infiltration of LAG3+ cells may induce immune escape in tumors with fewer IFN-γ+ cells and perforin-1+ cells and more Treg cells and M2 macrophages in this subtype of gastric cancer (87), similar results can be found in MIBC and pancreatic ductal adenocarcinoma (56, 88).