Furthermore, it is well known that IFN-γ has been shown to exhibit antitumor activity both in vitro and in vivo, and deficiencies in IFN-γ (IFN-γ−/−) or the IFN-γ receptor (IFN-γR−/−) promote tumor development in mice (58, 59). The gene discussed is IFNG; the disease is neoplasm.