SOD1 and amyotrophic lateral sclerosis: According to studies, both genetic (5) (e.g., C9ORF72, SOD1, TARDB, and FUS genes) (6, 7) and environmental factors (dietary habits, body mass index (BMI), smoking, alcohol consumption, etc.)are proposed as two main factors involved in ALS pathogenesis (Table 1) (5, 8, 10, 13).