However, not all patients with antibodies to intracellular neuronal antigens have evidence of an antigen-specific T cell response: lymphocytic infiltrates have been absent in the brains of some patients with anti-Yo associated paraneoplastic cerebellar degeneration (14, 92); and some investigators have failed to detect cytotoxic T lymphocytes in serum or CSF of patients with anti-Hu antibodies and paraneoplastic neurological disease (93–95). Here, CDR2 is linked to cerebellar degeneration.