CDR2 and cerebellar degeneration: In the case of paraneoplastic cerebellar degeneration associated with anti-Yo antibody, work by Panja et al. suggests that minimizing intracellular calcium overload toxicity either directly with cyclosporin-A or indirectly with cannabidiol or the ROS scavenger butylated hydroxytoluene could potentially provide neuroprotection by stabilizing mitochondrial calcium homeostasis (110, 113).