Similarly, in a hemorrhage induced sepsis mouse model, intratracheal delivery of siRNA to locally silence chemoattractant cytokines KC and MIP-2 significantly suppressed neutrophil influx into the lungs and decreased tissue or plasma level of IL-6, MIP-2 and MPO, activity (Lomas-Neira et al., 2005). This evidence concerns the gene CXCL2 and hemorrhage.