In a sepsis model of cecal ligation and puncture (CLP), tail-vein injection of synthetic double stranded oligodeoxynucleotides (ODNs) to decoy NF-κB showed protective effects on septic lung injury, such as decreased transcription of sepsis-induced proinflammatory genes (iNOS, COX-2), decreased histological damage in terms of alveolar wall thickening, immune cell infiltration and hemorrhage, decreased vascular permeability, and improved blood gas exchange capacity (Matsuda et al., 2005). Here, NFKB1 is linked to Sepsis.