ALDH7A1 and infection: It is instead focused on two themes: 1) That there is a place for academic laboratories to make contributions to the discovery and development of PDE inhibitors using methods not traditionally employed by the pharmaceutical industry that has dominated this field, and 2) that the PDEs of parasitic organisms can serve as drug targets to treat infections that involve a host’s immune system and produce an inflammatory response (thus, an appropriate topic for this volume).