In vitro research, we discovered that TGF-β1 caused the inhibition of E-cadherin and Bax and the boost of Vimentin, Fibronectin, Snail, p-AKT, p-GSK3β, and Bcl-2, while the above effects were overturned by serum-containing MSJZD, exhibiting that MSJZD restrained EMT and induced apoptosis through the AKT/GSK3β pathway, thereby repressing the migration, invasion, and promoting apoptosis of NSCLC cells. This evidence concerns the gene SNAI1 and non-small cell lung carcinoma.