The inflammatory cytokines, such as interleukin-1β (IL-1β) which is primarily driven by NF-κB and/or NLRP3 inflammasome activation, were related to islet inflammation and insulin secretion as well as the development of insulin resistance (Boni-Schnetzler and Donath, 2011). The gene discussed is NFKB1; the disease is Insulin resistance.