This compound possesses antihypertensive and antiarrhythmic properties in Ren-2 transgenic rats (TGR), inhibits sodium transport, protects vascular endothelial function, and blocks renal tubular sodium channel in ANG II-dependent hypertension (Khan et al., 2014, Hye Khan et al., 2014; Jíchová Š. The gene discussed is AGT; the disease is hypertensive disorder.