To test the idea that effective anti-sickling furan agents acted on both HbS and AQP1, red blood cells from human SCD patients were tested with 5-NMFC which modifies Hb, in combination with the bumetanide derivative AqB011 which blocks AQP1 ion channels (Kourghi et al., 2016). This evidence concerns the gene GSTM1 and Schnyder corneal dystrophy.