IL4 and ischemic stroke: The possible explanation is that the anti-inflammatory factor IL-4 acts by binding to the IL-4 receptor, enhancing the IL-4 signaling pathway, reducing the incidence of ischemic stroke, and promoting recovery after ischemic stroke (Xiong et al., 2011; Ferreira et al., 2014; Liu et al., 2016; Lively et al., 2016; Chen et al., 2020).