Cav1.2 channels are located in the cardiovascular system, the nervous system, and endocrine glands (Mikami et al., 1989), where they serve important physiopathological functions; for example, gain-of-function mutations in the CACNA1C gene cause Timothy Syndrome (Splawski et al., 2004; Moon et al., 2018). The gene discussed is CACNA1C; the disease is Timothy syndrome.