For instance, SCARB1 encodes high-density lipoprotein receptor that regulates cholesterol efflux from the peripheral tissue to the liver, is present in astrocytes and vascular smooth muscle cells in AD brain, and has been demonstrated to mediate adhesion of microglia to fibrillar amyloid-β (Aβ) (El Khoury et al., 1996; Thanopoulou et al., 2010; Jawaid and Khalil, 2011; Mulder et al., 2012). Here, SCARB1 is linked to Alzheimer disease.