Consistent with this, we have reported that the elevated TNF level in an APP/PS1 mouse model of AD generates an aberrant engagement of the heterodendritic metaplasticity mechanism responsible for the LTP impairment in these mice8, consistent with the efficacy of a scavenger biologic (XPro1585) in rescuing LTP in a 5xFAD mouse model60. The gene discussed is APP; the disease is Alzheimer disease.