YAP1 and colorectal carcinoma: With respect to radiosensitivity, CRC cells with ANKHD1 or MALAT1 silencing had significantly increased γH2AX foci-forming ability post IR, whereas YAP1 overexpression largely abrogated ANKHD1 or MALAT1-silencing-induced DNA damage in CRC cells (Fig. 7B, C, B: γH2AX foci at 0.5 h post IR).