NR2F1 and neoplasm: We found that, while the overall number of disseminated tumor cells is reduced in clodronate liposome treated animals36,49,57, of the cells that do disseminate, there is a significant reduction in the fraction that are positive for NR2F1 in CTCs and in disseminated tumor cells found in the lungs, as well as in the primary tumor, compared to control animals (Fig. 8d).