NR2F1 and neoplasm: As with NR2F1, we found only a small population (4%) of SOX9High cells in the primary tumor (Fig. 4d, “Primary Tumor” bar), but a dramatic enrichment of SOX9High CTCs (39%, a ~10-fold increase, Fig. 4d, “CTCs” bar), suggesting that tumor cells are programmed for stemness in the primary tumor, before, or during intravasation.