In different cancers, RBM5-AS1 was found to promote stem-like properties of colon cancer cells by recruiting β-catenin to the promoter regions of Wnt signaling target genes [9], RBM5-AS1 facilitates osteosarcoma cells [11], oral squamous cell carcinoma cells [12], and hepatocarcinoma cells [10] proliferation and metastasis through regulating RBM5, miR-1285-3p/YAP1 axis and silencing miR-132/212, respectively. Here, RBM5 is linked to malignant colon neoplasm.